2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-124320
    Desmethylene paroxetine hydrochloride
    		99.9%
    Desmethylene paroxetine hydrochloride is a major urinary metabolite of Paroxetine. Paroxetine is a potent serotonin reuptake inhibitor.
    Desmethylene paroxetine hydrochloride
  • HY-118100
    Cyclo(Tyr-Val)
    Cyclo(Tyr-Val) (Cyclo(L-Tyr-L-Val)) is a diketopiperazine secondary fungal metabolite originally isolated from N. gilva.
    Cyclo(Tyr-Val)
  • HY-G0017S1
    N-Desmethyl imatinib-d4
    N-Desmethyl imatinib-d4 is the deuterium-labeled N-Desmethyl imatinib (HY-G0017). N‑Desmethyl imatinib (Norimatinib) is an active metabolite of Imatinib (HY-15463), a selective c‑Abl inhibitor, and a substrate of P‑glycoprotein. N-Desmethyl imatinib binds to the c-Abl catalytic domain to prevent substrate phosphorylation, inhibits c-Abl-mediated α-synuclein activation and downstream inflammatory signaling pathways. N-Desmethyl imatinib induces apoptosis in K562 human leukemia cells. N-Desmethyl imatinib exhibits significantly elevated plasma levels in gastrointestinal stromal tumor (GIST) settings following mild SARS CoV 2 infection. N-Desmethyl imatinib can be used for the research of Parkinson’s disease, gastrointestinal stromal tumor, and chronic myeloid leukemia.
    N-Desmethyl imatinib-d<sub>4</sub>
  • HY-14798R
    Palifosfamide (Standard)
    Benzimidazole (Standard) is the analytical standard of Benzimidazole. This product is intended for research and analytical applications. Benzimidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Palifosfamide (Standard)
  • HY-136487
    Buspirone N-oxide
    Buspirone N-oxide (Bu N-oxide) is a metabolite of Buspirone (HY-B1115A). Buspirone is an orally active 5-HT1A receptor agonist, and a dopamine D2 autoreceptorsant antagonist. Buspirone is an anxiolytic agent, and can be used for the generalized anxiety disorder research.
    Buspirone N-oxide
  • HY-W424792A
    O-Desmethyl Brinzolamide hydrochloride
    O-Desmethyl Brinzolamide hydrochloride (compound 6a), an active metabolite of Brinzolamide, is a carbonic anhydrase (CA) inhibitor with a Kd of 0.136 nM for CA II and an IC50 of 165 nM for CA IV.
    O-Desmethyl Brinzolamide hydrochloride
  • HY-170056
    2α-Methyl-5α-androstan-17-one-3α-glucuronide
    2α-Methyl-5α-androstan-17-one-3α-glucuronide is a metabolite of Drostanolone.
    2α-Methyl-5α-androstan-17-one-3α-glucuronide
  • HY-12769S1
    Mebeverine acid-d5 hydrochloride
    		99.0%
    Mebeverine acid-d5 (Mebeverine metabolite Mebeverine acid-d5) hydrochloride is deuterium labeled Mebeverine acid hydrochloride. Mebeverine acid hydrochloride is a secondary metabolite of the intestinal antispasmodic agent Mebeverine (HY-A0078). Mebeverine acid hydrochloride is generated by the hydrolysis of Mebeverine in the body and is considered a key circulating metabolite. Mebeverine acid hydrochloride is an important marker for oral Mebeverine.
    Mebeverine acid-d<sub>5</sub> hydrochloride
  • HY-135563
    Oxoprolintane
    Oxoprolintane is a metabolite of the psychoactive compound Prolintane (HY-124217). Oxoprolintane has a role in regulating the central nervous system and may be a potential neuroprotective agent. Oxoprolintane is expected to be used in research on neurological diseases.
    Oxoprolintane
  • HY-134242A
    6-T-5'-GMP
    6-T-5'-GMP (6-Thioguanosine monophosphate) is an analogue of guanosine-5'-O-monophosphate (5'-GMP) and a metabolite of an immunosuppressive drug, Azathioprine (HY-B0256).
    6-T-5'-GMP
  • HY-123309
    Tilnoprofenic acid
    Tilnoprofenic acid (Y-9223) is a Y-23023 metabolite, cyclo-oxygenase inhibitor. Tilnoprofenic acid inhibits IL-6 production. Tilnoprofenic acid can be used in the research of blood disorders.
    Tilnoprofenic acid
  • HY-135746R
    OR-1896 (Standard)
    7-epi-Taxol (Standard) is the analytical standard of 7-epi-Taxol. This product is intended for research and analytical applications. 7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.
    OR-1896 (Standard)
  • HY-123165
    NU7200
    NU7200 is a metabolite of the DNA-PK inhibitor NU7026 (HY-15719).
    NU7200
  • HY-171459S
    LEQ803-d3
    LEQ803-d3 (N-Desmethyl Ribociclib-d3) is the deuterium labeled LEQ803 (HY-171459). LEQ803 (N-Desmethyl Ribociclib) is a drug metabolite of the CDK4/6 inhibitor Ribociclib (HY-15777), which is produced through metabolism by CYP3A4. LEQ803 has potential application value in the field of oncology.
    LEQ803-d<sub>3</sub>
  • HY-118099R
    Florfenicol amine hydrochloride (Standard)
    Florfenicol amine hydrochloride (Standard) is the analytical standard of Florfenicol amine hydrochloride. This product is intended for research and analytical applications. Florfenicol amine hydrochloride is a metabolite of Florfenicol (HY-B1374). Florfenicol inhibits bacterial protein synthesis by binding to 50S and 70S subunits in the ribosome to abolish the activity of peptidyltransferase. Florfenicol, is a veterinary antibiotic, can be used in aquaculture to control susceptible bacterial diseases.
    Florfenicol amine hydrochloride (Standard)
  • HY-W740426
    N-Desmethyl topotecan
    N-Desmethyltopotecan is a metabolite of Topotecan (HY-13768), and it can be detected in plasma, urine and feces.
    N-Desmethyl topotecan
  • HY-132995A
    DP-1 hydrochloride
    DP-1 hydrochloride, a degradation product of SDC-TRAP-0063, is a fragment of Ganetespib. Ganetespib is a heat shock protein 90 (HSP90) inhibitor with anti-tumor activity.
    DP-1 hydrochloride
  • HY-W088846
    7-Aminonimetazepam
    7-Aminonimetazepam is the metabolite of Nimetazepam, which is found in the urine.
    7-Aminonimetazepam
  • HY-W753452
    N,N-Dimethyltryptamine N-oxide-d6
    N,N-Dimethyltryptamine N-oxide-d6 is the deuterium labeled N,N-Dimethyltryptamine N-oxide (HY-W576312). N,N-Dimethyltryptamine N-oxide is a metabolite of N,N-Dimethyltryptamine.
    N,N-Dimethyltryptamine N-oxide-d<sub>6</sub>
  • HY-W012187R
    3,5-Di-tert-butyl-4-hydroxybenzaldehyde (Standard)
    3,5-Di-tert-butyl-4-hydroxybenzaldehyde (Standard) is the analytical standard of 3,5-Di-tert-butyl-4-hydroxybenzaldehyde. This product is intended for research and analytical applications. 3,5-Di-tert-butyl-4-hydroxybenzaldehyde (BHT-CHO) is a metabolite of Butylated hydroxytoluene (HY-Y0172) .
    3,5-Di-tert-butyl-4-hydroxybenzaldehyde (Standard)
Cat. No. Product Name / Synonyms Application Reactivity